OneCrea Medical

Next Generation Transcatheter Aortic Valve Replacement

Next Generation Transcatheter Aortic Valve  Replacement

About Us

Onecrea Medical, Inc. is a leading heart valve therapy research & development and manufacturing company located in California, USA. We are a dedicated team bringing the next generation TAVR manufactured from the patented technology from Cleveland Clinic to better human life.

Our team is comprised of talented scientists, engineers, and clinical professionals dedicated to providing state of the art, next generation TAVI/TAVR technology.

Our unparalleled expertise in the heart valve area allows us to bring a world class TAVR system which excels in safety and effectiveness. Our team strives to leverage considerable experience to bring the CreaValve TAVR system to patients and healthcare providers in all parts of the world.

Scientific Advisory Team:

Dr. Carlos Calderas

Dr. Carlos Calderas MD is a world-renowned interventional cardiologist at Policlínica Metropolitana in Caracas, Venezuela.

With over two decades of professional experience, Dr. Calderas focuses on conditions such as structural heart disease interventions and specializes in Transcatheter Aortic Valve Implantation (TAVI), Left Atrial Appendage Closure, and Percutaneous Paravalvular Leak Closure, among other advanced interventions. 

He has conducted several FIH studies including coronary and structural heart devices. He is a contributor to CITIC, TCT, and other interventional cardiology congresses. He is the coordinator of the interventional cardiology session of the Venezuelan Society of Cardiology. Dr. Calderas has an impressive academic portfolio, having been published in many journals and publications.

Dr. Flavio Ribichini

Professor Ribichini serves as the Director of the School of Cardiovascular Medicine and Post-Graduate Fellowship at the University of Verona. 

He is also the Chairman of the Cardiothoracic Department of the University Hospitals, one of the largest and most prestigious medical Institutions in Italy.

Throughout his career, Prof. Ribichini has exhibited active engagement within multiple international cardiology groups such as the Editorial Board of the European Heart Journal, the Scientific Board of PCR, the Guidelines task force of the European Society of Cardiology, and the Board of Directors of the EAPCI (European Association of Percutaneous Cardiac Interventions.

His passion for research and education is evident through his Research Fellow appointments at several European and US Institutions, such as Stanford University and the OLVZ Cardiovascular Centre in Aalst, Belgium. In over 30 years of clinical work as an interventional cardiologist and research in the field, Prof. Ribichini’s scholarly impact shines through with a substantial portfolio of over 400 full publications in peer-reviewed scientific journals indexed in PubMed, encompassing clinical and basic cardiovascular research.

Dr. Ramiro Trillo

Dr. Ramiro Trillo heads the Interventional Cardiology Department at the University Hospital in Santiago de Compostela, Spain.

With an impressive track record spanning over 25 years, Dr. Trillo is a seasoned Interventional Cardiologist renowned for his expertise in various domains. His primary focus lies in Structural Heart Disease Interventions, encompassing intricate procedures such as Transcatheter Aortic Valve Implantation, Edge-to-Edge Mitral and Tricuspid Valve Repair, Percutaneous Tricuspid Annuloplasty, Left Atrial Appendage Closure, and Percutaneous Paravalvular Leak Closure, among other advanced interventions.

Dr. Trillo’s leadership and influence extend beyond his practice. He has previously held the position of Past-President within the Interventional Cardiology Association of the Spanish Society of Cardiology. Moreover, he served as the Past Co-Chair of the Education and Training Committee for the European Association of Percutaneous Cardiac Interventions within the European Society of Cardiology. Notably, his expertise is acknowledged by his role as a Proctor and Trainer for Transcatheter Aortic Valve Implantation Procedures, underscoring his commitment to imparting knowledge and advancing the field.

Dr. Maurizio Taramasso

Professor Maurizio Taramasso is a cardiac surgeon and structural interventionalist at HerzZentrum Hirslanden Zürich, Klinik Hirslanden, Zurich, Switzerland. He completed his surgical training at the San Raffaele University Hospital in Milan, Italy, in 2014.

His expertise extends to specific cross-training in interventional cardiology and heart valve transcatheter therapies, particularly in mitral and aortic procedures, at the same institution.

In 2012, he further honed his skills through a Fellowship in Aortic Surgery at the Hannover Medical School. Professor Taramasso’s primary focus lies in both surgical and catheter treatments of valvular heart disease, including transfemoral and transapical TAVI, as well as MitraClip interventions for heart failure. His contributions to the field are evident in numerous publications on these topics, and he has been recognized with the prestigious “Thomas J. Linnemeier Spirit of Interventional Cardiology Young Investigator Award” in Denver, Colorado, USA. This accolade is bestowed annually during the Transcatheter Cardiovascular Therapeutics (TCT) conference, the foremost gathering in the world for interventional cardiology.

Dr. Carla Agiatello

Dr. Agatiello obtained her degree from the Faculty of Medicine of the University of Buenos Aires in 1998 and in 2002 she completed her specialization and training in Cardiology at the Hospital Israelita de Buenos Aires. Subsequently, she completed a specialization in Interventional Cardiology at the University of Rouen and at the University of Créteil & Necker (Paris, France), where she obtained her diploma in 2005.

She was fellowship trained in Interventional Cardiology and focused on heart valve disease at the Charles Nicole Hospital (Rouen, France) over a period of 3 years.

 Immediately afterward, Dr. Agatiello returned to Argentina to work with Liliana Grinfeld MD, PhD in the Department of Interventional Cardiology at the Hospital Italiano de Buenos Aires.

 She is currently Head of the Department of Interventional Cardiology at the Hospital Italiano de Buenos Aires and performs interventional cardiology procedures daily focused on heart valve replacement.

In turn, she is director of the MIL Group (Women Interventional Cardiologists in Latin America) and coordinates the activities of Women as an NGO in Latin America on behalf of SOLACI and CACI. Actually, Dr. Agatiello is the President of the scientific SOLACI-CACI2024 Meeting to be held in Buenos Aires this year. She has vast experience as a researcher, having published more than 100 scientific articles in indexed and non-indexed journals.

News

Onecrea Medical completes first-in-human implants of TAVR system

July 21, 2023
The company designed next-generation TAVR system to treat aortic stenosis…

Onecrea Medical announces successful first-in-human implants

July 20, 2023
First-in-human implants of its transcatheter aortic valve implantation…

Successful Completion of the First-in-human Implants of the Crea

July 21, 2023
While TAVR technology has been around since 2007, Onecrea Medical’s team …

Onecrea Medical completes first-in-human implants of TAVR system

July 21, 2023
Onecrea Medical recently announced that it successfully completed first-in-human…

Events

CITIC 2023 Mexico City

Dr. Carlos Calderas presenting Crea Aortic Valve under Innovative and Next Generation TAVI …

EuroPCR 2024 Paris

Dr. Flavio Ribichini presented the first-in-man study for the Crea Aortic Valve at EuroPCR, the largest congress for interventional cardiovascular medicine.

SOLACI 2024 Buenos Aires

Come learn more about the Crea Aortic Valve at the largest interventional cardiologist meeting in Latin America. 

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Dr. Carlos Calderas presenting Crea Aortic Valve under Innovative and Next Generation TAVI in CITIC 2023, Mexico City, Mexico.

CITIC is a training center for scientific, academic, research and communication resources where specialists in the cardiovascular area and doctors in training can find a platform for updating and communication with national and international experts in the area of ​​imaging and technology in cardiovascular intervention.

Dr. Flavio Ribichini presenting the 1-year data for the first Crea Aortic Valve patients.

EuroPCR is one of the largest international congresses for interventional cardiologists. Here, Dr. Flavio Ribichini presented the 1-year data for the first 3 patients of the Crea Aortic Valve (CAV). These cases were performed by Dr. Carlos Calderas in Venezuela. The patients were 3 elderly women with small aortic annuli and severe symptomatic aortic stenosis. All 3 patients had excellent hemodynamic data 1-year after implantation, including single-digit aortic mean gradients and trivial or no paravalvular leak. Additionally, the Vmax of all 3 patients was less than 2 m/s at 1 year. Interestingly, much of the hemodynamic data improved as time went on indicating the success of the self-anchoring and self-centering technology.

Onecrea Medical's Scientific Advisory Board Members and CEO

From Left to Right: Dr. Flavio Ribichini, Dr. Carlos Calderas, Dr. Maurizio Taramasso, Onecrea Medical CEO Kris Kupumbati

Crea Aortic Valve E-Poster on display in the Innovators Session